NOVEL NA+/CA2+ EXCHANGER INHIBITOR ORM-10962 SUPPORTS COUPLED FUNCTION OF FUNNY-CURRENT AND NA+/CA2+ EXCHANGER IN PACEMAKING OF RABBIT SINUS NODE TISSUE

Novel Na+/Ca2+ Exchanger Inhibitor ORM-10962 Supports Coupled Function of Funny-Current and Na+/Ca2+ Exchanger in Pacemaking of Rabbit Sinus Node Tissue

Background and PurposeThe exact mechanism of spontaneous pacemaking is not fully understood.Recent results suggest tight cooperation between intracellular Ca2+ handling and sarcolemmal ion channels.An important player of this crosstalk is the Na+/Ca2+ exchanger (NCX), however, direct pharmacological evidence was unavailable so far because of the la

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